0001538210-24-000008 | 10-Q | XBRL Viewer

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Fair Value Measurements - Schedule of Fair Value Assets and Liabilities Measured on Recurring Basis (Detail) - USD ($)	Mar. 31, 2024	Dec. 31, 2023
Liabilities
Warrant liability	$ 1,389,543	$ 0
Warrants representing shares of common stock (in shares)	304,731
Level 1 \| Recurring basis
Assets
Total assets	$ 23,454	23,270
Liabilities
Warrant liability	0	0
Total liabilities	0	0
Level 1 \| Money market funds \| Recurring basis
Assets
Money market funds	23,454	23,270
Level 2 \| Recurring basis
Assets
Total assets	0	0
Liabilities
Warrant liability	0	0
Total liabilities	0	0
Level 2 \| Money market funds \| Recurring basis
Assets
Money market funds	0	0
Level 3 \| Recurring basis
Assets
Total assets	0	0
Liabilities
Warrant liability	1,389,543	0
Total liabilities	1,389,543	0
Level 3 \| Money market funds \| Recurring basis
Assets
Money market funds	$ 0	$ 0

Stock-Based Compensation - Summary of Option Activity (Detail) - USD ($) $ / shares in Units, $ in Millions	3 Months Ended		12 Months Ended
	Mar. 31, 2024	Mar. 31, 2023	Dec. 31, 2023
Stock Options
Outstanding as of beginning of period (in shares)	130,526
Granted (in shares)	0	0
Exercised (in shares)	0	0
Cancelled (in shares)	(11,287)
Forfeited (in shares)	0
Outstanding as of end of period (in shares)	119,239		130,526
Vested or expected to vest by period end (in shares)	119,239
Exercisable as of period end (in shares)	72,030
Shares unvested as of period end (in shares)	47,209
Weighted Average Exercise Price
Outstanding as of beginning of period (in dollars per share)	$ 28.64
Granted (in dollars per share)	0
Exercised (in dollars per share)	0
Cancelled (in dollars per share)	21.50
Forfeited (in dollars per share)	0
Outstanding as of end of period (in dollars per share)	29.32		$ 28.64
Vested or expected to vest as of end of period (in dollars per share)	29.32
Exercisable as of end of period (in dollars per share)	39.37
Shares unvested as of end of period (in dollars per share)	$ 13.99
Weighted Average Remaining Contractual Term (years)
Outstanding as of end of period (in years)	7 years 2 months 12 days		7 years 3 months 18 days
Vested or expected to vest as of end of period (in years)	7 years 2 months 12 days
Exercisable as of end of period (in years)	6 years 1 month 6 days
Shares unvested as of end of period (in years)	8 years 7 months 6 days
Aggregate Intrinsic Value (in millions)
Outstanding as of March 31, 2024	$ 0.0		$ 0.0
Vested or expected to vest as of March 31, 2024	0.0
Exercisable as of March 31, 2024	0.0
Shares unvested as of March 31, 2024	$ 0.0

Property and Equipment (Tables)

3 Months Ended

Mar. 31, 2024

Property, Plant and Equipment [Abstract]

Summary of Property and Equipment

Property and equipment consist of the following at March 31, 2024 and December 31, 2023:


	March 31, 2024		December 31, 2023
Laboratory equipment	$	2,668,280	$	2,668,280
Computer equipment and software	202,963		202,963

Leasehold improvements	36,459		36,459
	2,907,702		2,907,702
Less accumulated depreciation and amortization	(1,669,713)		(1,554,801)
Total property and equipment, net	$	1,237,989	$	1,352,901

Stock-Based Compensation - Additional Information (Detail)	1 Months Ended	3 Months Ended
	Feb. 28, 2021	Mar. 31, 2024 USD ($) shares	Mar. 31, 2023 shares	Dec. 31, 2023 shares	Apr. 04, 2023 shares	Mar. 22, 2023 $ / shares	Sep. 30, 2018 shares	Jul. 31, 2018 shares	Mar. 01, 2017 shares
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share price (in dollars per share) \| $ / shares						$ 0.41
Share-based compensation arrangement by share-based payment award, options, outstanding (in shares)		119,239		130,526
Granted (in shares)		0	0
Exercise of stock options (in shares)		0	0
Unrecognized compensation expense \| $		$ 1,600,000
Employees Excluding Executive Officer \| Tranche One
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share based payment arrangement, option, repricing multiple						2.5
Share based payment arrangement, option, repricing exercise price (in dollars per share) \| $ / shares						$ 25.75
Employees Excluding Executive Officer \| Tranche Two
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share based payment arrangement, option, repricing exercise price (in dollars per share) \| $ / shares						$ 10.25
Executive Officer \| Jerome Zeldis
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-based compensation arrangement by share-based payment award, options, outstanding (in shares)					100,000
Executive Officer \| Tranche One
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share based payment arrangement, option, repricing multiple						3.0
Share based payment arrangement, option, repricing exercise price (in dollars per share) \| $ / shares						$ 30.75
Executive Officer \| Tranche Two
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share based payment arrangement, option, repricing multiple						2.0
Share based payment arrangement, option, repricing exercise price (in dollars per share) \| $ / shares						$ 20.50
Director \| Tranche One
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share based payment arrangement, option, repricing multiple						4.0
Share based payment arrangement, option, repricing exercise price (in dollars per share) \| $ / shares						$ 41.00
Director \| Tranche Two
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share based payment arrangement, option, repricing multiple						3.0
Share based payment arrangement, option, repricing exercise price (in dollars per share) \| $ / shares						$ 30.75
Stock options
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Unrecognized compensation expense period for recognition		1 year 8 months 12 days
Restricted stock unit
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Service period for award		18 months
Restricted stock awarded (in shares)		0
Unrecognized compensation expense period for recognition		1 month 24 days
Unrecognized compensation expense \| $		$ 37,441
Maximum \| Stock options
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-based payment arrangement, plan modification, incremental cost \| $		$ 300,000
The 2017 Plan
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Shares reserved (in shares)									26,433
Shares available for issuance (in shares)		0
The 2018 Plan
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Shares reserved (in shares)							69,670	72,365
Shares available for issuance (in shares)		0
The 2021 Plan
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Shares available for issuance (in shares)		150,944
Award expiration period	10 years
The 2021 Plan \| Minimum
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Award vesting period	1 year
The 2021 Plan \| Maximum
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Award vesting period	4 years

Fair Value Measurements (Tables)

3 Months Ended

Mar. 31, 2024

Fair Value Disclosures [Abstract]

Schedule of Fair Value Assets and Liabilities Measured on Recurring Basis

The following table represents the Company’s fair value hierarchy for its financial assets measured at fair value on a recurring basis:


	March 31, 2024						December 31, 2023
	Level 1		Level 2		Level 3		Level 1		Level 2		Level 3
Assets
Money market funds	$	23,454	$	—	$	—	$	23,270	$	—	$	—

	$	23,454	$	—	$	—	$	23,270	$	—	$	—
Liabilities
Warrant liability	—		—		1,389,543		—		—		—
	$	—	$	—	$	1,389,543	$	—	$	—	$	—

Summary of Measurement Inputs and Valuation Techniques

The Company used the following key assumptions within its valuation. In all scenarios, the Company also applied the likelihood of a fundamental transaction and the related impact on the Common Stock price and volatility.


	February 6, 2024			March 31, 2024
Common stock price per share	$	10.51		$	5.61
Exercise price per share	$	12.05		$	12.05
Expected volatility	176.0		%	173.3		%
Risk-free interest rate	4.34		%	4.60		%
Contractual term (in years)	2			1.9

Schedule of Warrant Liability

The following is a roll forward of the fair value of Level 3 warrants:


	Warrant Liability Fair Value
Balance as of December 31, 2023	$	—
Warrants issued	2,810,382
Change in fair value	(1,420,839)
Balance as of March 31, 2024	$	1,389,543

STATEMENTS OF CASH FLOWS (UNAUDITED) - USD ($)	3 Months Ended
STATEMENTS OF CASH FLOWS (UNAUDITED) - USD ($)	Mar. 31, 2024	Mar. 31, 2023
Cash flows from operating activities
Net loss	$ (3,077,273)	$ (9,565,077)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	114,912	263,766
Gain on sale of assets held for sale	(74,872)	0
Change in fair value of warrant liability	(1,420,839)	0
Offering costs associated with warrant liabilities	740,836	0
Loss on issuance of common stock and warrants	1,111,614	0
Stock-based compensation	348,301	842,446
Non-cash lease expense	46,716	130,740
Changes in operating assets and liabilities:
Prepaid expenses and other assets	161,699	(288,687)
Other non-current assets	82,772	0
Accounts payable	(564,704)	(1,726,806)
Accrued expenses	183,589	(1,804,135)
Operating lease liabilities	(68,809)	(136,652)
Net cash used in operating activities	(2,416,058)	(12,284,405)
Cash flows from investing activities
Purchase of property and equipment	0	(42,720)
Proceeds from disposal of equipment	522,555	0
Net cash provided by (used in) investing activities	522,555	(42,720)
Cash flows from financing activities
Proceeds from issuance of common stock and warrants, net of issuance costs	3,143,949	0
Net cash provided by financing activities	3,143,949	0
Net increase (decrease) in cash, cash equivalents and restricted cash	1,250,446	(12,327,125)
Cash, cash equivalents and restricted cash at beginning of period	3,222,452	34,697,340
Cash, cash equivalents and restricted cash at end of period	$ 4,472,898	$ 22,370,215

Fair Value Measurements - Schedule of Warrant Liability (Details) - USD ($)	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Warrant Liability, Fair Value [Roll Forward]
Balance as of December 31, 2023	$ 0
Change in fair value	(1,420,839)	$ 0
Balance as of March 31, 2024	1,389,543
Level 3
Warrant Liability, Fair Value [Roll Forward]
Warrants issued	2,810,382
Change in fair value	(1,420,839)
Level 3 \| Recurring basis
Warrant Liability, Fair Value [Roll Forward]
Balance as of December 31, 2023	0
Balance as of March 31, 2024	$ 1,389,543

Nature of the Business	3 Months Ended
Nature of the Business	Mar. 31, 2024
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Nature of the Business	Nature of the Business NexImmune, Inc. (“Company,” “we,” “us” or “NexImmune”), a Delaware corporation headquartered in Gaithersburg, Maryland, was incorporated on June 7, 2011. The Company is an emerging biopharmaceutical company advancing a new generation of immunotherapies based on its proprietary Artificial Immune Modulation ("AIMTM") technology. The AIM nanotechnology platform, originally developed at Johns Hopkins University, is the foundation for an innovative approach to immunotherapy in which the body’s own immune system is stimulated to orchestrate a targeted T cell response against a disease. Central to the AIM technology are artificial AIM nanoparticles, which act as synthetic dendritic cells. These AIM nanoparticles can be programmed to present specific antigens to specific T cells orchestrating a highly targeted immune response. These AIM nanoparticles can be rapidly engineered to elicit an immune attack that can be directed toward any foreign substance or cell type in a patient’s body. The Company’s first two products, both for the treatment of different types of cancer, entered clinical trials in 2020. Following a strategic review of the Company's corporate strategy, including with respect to its adoptive cell therapy programs, the Company paused clinical development of its current AIM Adoptive Cell Therapy product candidates, NEXI-001 in Acute Myeloid Leukemia, NEXI-002 in Multiple Myeloma, and NEXI-003 in HPV related solid tumors which is designed to reduce costs and reallocate resources towards our AIM in vivo directly-injectable modality (“INJ”) preclinical development programs. As part of this strategy, the Company will focus on developing AIM INJ nanoparticle constructs and modalities for potential clinical evaluation in oncology and autoimmune disorders. The Company continues to explore several external opportunities to continue to advance these programs. As a result, the Company will focus its existing resources on its injectable platform in oncology and autoimmune diseases. Going Concern Financial Accounting Standards Board ("FASB") Accounting Standards Codification ("ASC") Topic 205-40, Presentation of Financial Statements - Going Concern ("ASC 205-40"), requires management to assess the Company’s ability to continue as a going concern for one year after the date the financial statements are issued. Under ASC 205-40, management has the responsibility to evaluate whether conditions and/or events raise substantial doubt about the Company’s ability to meet future financial obligations as they become due within one year after the date that the unaudited financial statements are issued. As required by this standard, management’s evaluation shall initially not take into consideration the potential mitigating effects of management’s plans that have not been fully implemented as of the date the unaudited financial statements are issued. The accompanying unaudited financial statements have been prepared on a going concern basis, which contemplates the realization of assets and the satisfaction of liabilities in the normal course of business. The Company has incurred recurring operating losses and negative cash flows from operations. The unaudited financial statements do not include any adjustments relating to the realization of the carrying value of assets or the amounts and classification of liabilities that might be necessary should we be unable to continue as a going concern. As of March 31, 2024, the Company had an accumulated deficit of $225.7 million and negative cash flows from operating activities for the period ended March 31, 2024. The Company has no outstanding debt, $4.5 million in cash and cash equivalents as of March 31, 2024 and no other access to significant capital. The Company expects its negative cash flows from operating activities to exceed its currently available liquidity and thus has determined that its losses and negative cash flows from operations and uncertainty in obtaining additional liquidity sufficient to meet its obligations and sustain its operations raise substantial doubt about the Company’s ability to continue as a going concern for at least one year from the issuance date of these unaudited financial statements. As the Company’s research and development activities mature and develop over the next year, the Company will require substantial funds to continue such activities. As discussed below, as a result of the financing consummated in February 2024, the Company determined to postpone its previously scheduled special meeting of stockholders for the purpose of approving the liquidation and dissolution of the Company. If the Company is unable to raise additional capital or otherwise achieve other alternatives to maximize the value of the business and its assets, the Company would expect to call a new special meeting of stockholders to seek approval of the liquidation and dissolution of the Company. In this regard, management plans to raise additional capital through financing activities that may include public offerings and private placements of its common stock, preferred stock offerings, collaborations and licensing arrangements and issuances of debt and convertible debt instruments. There are inherent uncertainties associated with fundraising activities which are not within the Company’s control. There are no assurances that such additional funding will be obtained, or that any funding that may be obtained would be sufficient for the Company to meet its obligations as they become due within one year, or that the Company will succeed in its future operations. If the Company cannot successfully raise additional capital, its liquidity, financial condition and business prospects will be materially and adversely affected. The Company is continually looking into further capital planning and the evaluation of strategic alternatives. There is substantial doubt about the Company’s ability to continue as a going concern. Reverse Stock Split On October 18, 2023, the Company effected a one-for-twenty five (1-for-25) reverse stock split of its common stock (the “Reverse Stock Split”). The total authorized number of shares were not reduced. The Reverse Stock Split, which was approved by stockholders at a special stockholder meeting on October 17, 2023, was consummated pursuant to a Certificate of Amendment filed with the Secretary of State of Delaware on October 18, 2023. The Reverse Stock Split was effective on October 18, 2023. All references to common stock, warrants to purchase common stock, options to purchase common stock, share data, per share data and related information contained in the unaudited financial statements have been retrospectively adjusted to reflect the effect of the Reverse Stock Split for all periods presented. Approval of Plan of Dissolution and Postponement of Special Meeting On November 2, 2023, the Board of Directors of the Company (the "Board"), unanimously approved the liquidation and wind up of the Company through a dissolution pursuant to a plan of liquidation and dissolution (the "Plan of Liquidation and Dissolution"), subject to stockholder approval, while continuing to pursue alternatives intended to maximize the value of the business and its assets. On February 2, 2024, the Company entered into a securities purchase agreement (the “Purchase Agreement”) with a single healthcare focused institutional investor (the “Investor”), pursuant to which the Company agreed to issue and sell, in a registered direct offering priced at-the-market under the rules of The Nasdaq Stock Market (the “Registered Offering”) (i) an aggregate of 117,000 shares (the “Shares”) of common stock, par value $0.0001 per share, of the Company (“Common Stock”), at an offering price of $12.05 per share, and (ii) pre-funded warrants the “Pre-Funded Warrants” exercisable for up to 187,731 shares of Common Stock (the “Pre-Funded Warrant Shares”), at an offering price of $12.049 per Pre-Funded Warrant, for aggregate gross proceeds from the February 2024 Offerings (as defined below) of approximately $3.7 million before deducting the placement agent fee and related offering expenses. The February 2024 Offerings closed on February 6, 2024 and all Pre-Funded Warrants were exercised at closing. In a concurrent private placement (the “Private Placement” and, together with the Registered Offering, the “February 2024 Offerings”), the Company issued to the Investor unregistered warrants to purchase up to an aggregate of 304,731 shares of Common Stock (the “Unregistered Warrants”) at an exercise price of $12.05 per share. Each Unregistered Warrant is exercisable immediately and will expire two years from the initial exercise date. The Unregistered Warrants and the shares of our Common Stock issuable upon the exercise of the Unregistered Warrants are not being registered under the Securities Act of 1933, as amended (the “Securities Act”), are not being offered pursuant to the Registration Statement and are being offered pursuant to the exemption provided in Section 4(a)(2) under the Securities Act, and/or Rule 506(b) promulgated thereunder. As a result of the February 2024 Offerings described above, the Company has determined to postpone its special meeting of stockholders for the purpose of approving the liquidation and dissolution of the Company and the Plan of Liquidation and Dissolution, which was previously scheduled to reconvene on Wednesday, February 7, 2024.

Insider Trading Arrangements	3 Months Ended
Insider Trading Arrangements	Mar. 31, 2024
Trading Arrangements, by Individual
Rule 10b5-1 Arrangement Adopted	false
Non-Rule 10b5-1 Arrangement Adopted	false
Rule 10b5-1 Arrangement Terminated	false
Non-Rule 10b5-1 Arrangement Terminated	false

Stockholders’ Equity and Contingently Redeemable Warrants (Detail)				3 Months Ended		12 Months Ended
	Feb. 02, 2024 USD ($) $ / shares shares	Jun. 17, 2022 USD ($)	Mar. 09, 2022 USD ($)	Mar. 31, 2024 USD ($) $ / shares yr shares	Mar. 31, 2023 USD ($)	Dec. 31, 2023 USD ($) shares	Feb. 29, 2024 $ / shares shares	Feb. 06, 2024 $ / shares yr
Class of Stock [Line Items]
Authorized common stock (in shares) \| shares				250,000,000		250,000,000
Common stock, shares outstanding (in shares) \| shares				1,371,051		1,066,320
Common stock, shares issued (in shares) \| shares				1,371,051		1,066,320
Loss on issuance of common stock and warrants				$ 1,111,614	$ 0
Fundamental transaction clause, beneficial ownership percentage threshold				50.00%
Stock price
Class of Stock [Line Items]
Warrants measurement inputs \| $ / shares				5.61				10.51
Exercise price
Class of Stock [Line Items]
Warrants measurement inputs \| $ / shares				12.05				12.05
Expected stock price volatility
Class of Stock [Line Items]
Warrants measurement inputs				1.733				1.760
Expected life
Class of Stock [Line Items]
Warrants measurement inputs \| yr				1.9				2
Risk-free interest rate
Class of Stock [Line Items]
Warrants measurement inputs				0.0460				0.0434
Pre-Funded Warrants
Class of Stock [Line Items]
Warrants representing shares of common stock (in shares)				$ 2,000,000
Unregistered Warrants
Class of Stock [Line Items]
Warrants representing shares of common stock (in shares)				2,800,000
Unregistered PA Warrants
Class of Stock [Line Items]
Warrants representing shares of common stock (in shares)				$ 200,000
Unregistered PA Warrants \| Stock price
Class of Stock [Line Items]
Warrants measurement inputs \| $ / shares				10.51
Unregistered PA Warrants \| Exercise price
Class of Stock [Line Items]
Warrants measurement inputs \| $ / shares				15.06
Unregistered PA Warrants \| Expected stock price volatility
Class of Stock [Line Items]
Warrants measurement inputs				1.520
Unregistered PA Warrants \| Expected life
Class of Stock [Line Items]
Warrants measurement inputs \| yr				5
Unregistered PA Warrants \| Risk-free interest rate
Class of Stock [Line Items]
Warrants measurement inputs				0.0399
Unregistered PA Warrants \| Dividend yield
Class of Stock [Line Items]
Warrants measurement inputs				0
At-The-Market Offering
Class of Stock [Line Items]
Sale of stock, aggregate offering approval, maximum			$ 200,000,000
Sale of stock, aggregate offering approval		$ 50,000,000.0
Commission percentage		3.00%
Net proceeds from sale of stock				$ 0		$ 0
Registered Offering
Class of Stock [Line Items]
Shares issued (shares) \| shares	117,000
Offering price of common stock (in dollars per share) \| $ / shares	$ 12.05
Consideration received on transaction	$ 3,700,000
Payments of stock issuance costs				500,000
Registered Offering \| Pre-Funded Warrants
Class of Stock [Line Items]
Number of securities called by warrants (in shares) \| shares	187,731
Offering price of warrants (in dollars per share) \| $ / shares	$ 12.049
Payments of stock issuance costs				$ 500,000
The Private Placement \| Unregistered Warrants
Class of Stock [Line Items]
Number of securities called by warrants (in shares) \| shares	304,731						304,731
Exercise price of warrants (in dollars per share) \| $ / shares	$ 12.05						$ 12.05
Warrants, term	2 years
The Private Placement \| Unregistered PA Warrants
Class of Stock [Line Items]
Number of securities called by warrants (in shares) \| shares	21,331
Exercise price of warrants (in dollars per share) \| $ / shares	$ 15.0625
Warrants, term	5 years

Restructuring Activities - Summary of Charges Related to Restructuring Activities (Details)	3 Months Ended
	Mar. 31, 2024 USD ($)
Restructuring Reserve [Roll Forward]
Restructuring reserve, beginning balance	$ 266,537
Expenses	0
Less: Payments	(26,470)
Restructuring reserve, ending balance	240,067
Severance, benefits and related costs due to workforce reduction
Restructuring Reserve [Roll Forward]
Restructuring reserve, beginning balance	266,537
Expenses	0
Less: Payments	(26,470)
Restructuring reserve, ending balance	$ 240,067

Prepaid Expenses and Other Current Assets

3 Months Ended

Mar. 31, 2024

Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract]

Prepaid Expenses and Other Current Assets

Prepaid expenses and other current assets consist of the following at March 31, 2024 and December 31, 2023:


	March 31, 2024		December 31, 2023
Prepaid research and development expenses	$	121,385	$	115,353

Prepaid insurance	313,859		368,048
Prepaid other	87,636		35,817

Other current assets	66,330		215,246
Total prepaid expenses and other current assets	$	589,210	$	734,464

Property and Equipment - Summary of Property And Equipment (Detail) - USD ($)	Mar. 31, 2024	Dec. 31, 2023
Property, Plant and Equipment [Line Items]
Property plant and equipment gross	$ 2,907,702	$ 2,907,702
Less accumulated depreciation and amortization	(1,669,713)	(1,554,801)
Total property and equipment, net	1,237,989	1,352,901
Laboratory equipment
Property, Plant and Equipment [Line Items]
Property plant and equipment gross	2,668,280	2,668,280
Computer equipment and software
Property, Plant and Equipment [Line Items]
Property plant and equipment gross	202,963	202,963
Leasehold improvements
Property, Plant and Equipment [Line Items]
Property plant and equipment gross	$ 36,459	$ 36,459

Related Party Transaction (Details) - USD ($)		1 Months Ended	3 Months Ended
Related Party Transaction (Details) - USD ($)	Mar. 16, 2022	Jul. 31, 2023	Mar. 31, 2024	Mar. 31, 2023	Dec. 31, 2023
Related Party Transaction [Line Items]
JRA term	2 years
Related party transaction, amounts of transaction		$ 200,000
Other income (expense)			$ 97,014	$ (14,406)
Accrued expenses			3,862,694		$ 3,679,105
Related Party
Related Party Transaction [Line Items]
Other income (expense)			25,000	$ 0
Accrued expenses			$ 25,000

Assets Held For Sale (Details) - USD ($)	3 Months Ended		12 Months Ended
Assets Held For Sale (Details) - USD ($)	Mar. 31, 2024	Mar. 31, 2023	Dec. 31, 2023	Nov. 29, 2023
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract]
Costs to sell			$ 1,400,000
Carrying value of assets				$ 2,000,000
Loss on assets held for sale			700,000
Fair value of assets held for sale	$ 979,915	$ 0	$ 1,444,043
Disposal Group, Not Discontinued Operation, Gain (Loss) on Disposal	$ 74,872	$ 0

Accrued Expenses (Tables)

3 Months Ended

Mar. 31, 2024

Payables and Accruals [Abstract]

Summary of the Components of Accrued Expenses

A summary of the components of accrued expenses is as follows as of March 31, 2024 and December 31, 2023:


	March 31, 2024		December 31, 2023
Accrued research and development costs	$	3,224,274	$	3,148,021
Accrued salaries, benefits and related expenses	306,654		389,858
Accrued professional fees	149,950		131,226
Other accrued expenses	181,816		10,000
Total accrued expenses	$	3,862,694	$	3,679,105

Property and Equipment

3 Months Ended

Mar. 31, 2024

Property, Plant and Equipment [Abstract]

Property and Equipment

In November 2023, the Company terminated its primary lease and began moving equipment from its facility to be sold. The Company considered the criteria to classify the property and equipment as held for sale under ASC 360—Property, plant and equipment (Topic 360). Assets shall be classified as held for sale in the period in which all of the following criteria are met: a) Management commits to a plan to sell the entity to be sold. b) The assets to be sold are available for immediate sale in its present condition. c) An active program to locate a buyer or buyers is in place. d) The sale is probable and is expected to be completed within one year. e) The assets to be sold being actively marketed for sale at a price that is reasonable in relation to its current fair value. f) Actions required to complete the plan indicate that it is unlikely that significant changes to the plan will be made or that the plan will be withdrawn. The Company determined that all these criteria as of March 31, 2024 and December 31, 2023 were met for certain categories of the property and equipment, specifically certain computers and laboratory equipment. Accordingly, the computers and laboratory equipment being sold were classified as current assets held for sale at March 31, 2024 and December 31, 2023. See Note 7 for discussion on the Assets Held for Sale.

Property and equipment consist of the following at March 31, 2024 and December 31, 2023:


	March 31, 2024		December 31, 2023
Laboratory equipment	$	2,668,280	$	2,668,280
Computer equipment and software	202,963		202,963

Leasehold improvements	36,459		36,459
	2,907,702		2,907,702
Less accumulated depreciation and amortization	(1,669,713)		(1,554,801)
Total property and equipment, net	$	1,237,989	$	1,352,901

Depreciation and amortization expense was $0.1 million and $0.3 million for the three months ended March 31, 2024 and 2023, respectively

STATEMENTS OF CHANGES IN STOCKHOLDERS’ EQUITY (UNAUDITED) - USD ($)	Total	Common Stock	Additional Paid-In Capital	Accumulated Deficit
Beginning balance at Dec. 31, 2022	$ 0
Ending balance at Mar. 31, 2023	0
Beginning balance (in shares) at Dec. 31, 2022		1,043,138
Beginning balance at Dec. 31, 2022	32,300,484	$ 2,608	$ 222,547,530	$ (190,249,654)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Stock-based compensation	842,446		842,446
Net loss	(9,565,077)			(9,565,077)
Ending balance (in shares) at Mar. 31, 2023		1,043,138
Ending balance at Mar. 31, 2023	23,577,853	$ 2,608	223,389,976	(199,814,731)
Beginning balance at Dec. 31, 2023	0
Increase (Decrease) in Temporary Equity [Roll Forward]
Reclass warrants to temporary equity	224,189
Ending balance at Mar. 31, 2024	$ 224,189
Beginning balance (in shares) at Dec. 31, 2023	1,066,320	1,066,320
Beginning balance at Dec. 31, 2023	$ 3,509,717	$ 2,646	226,101,118	(222,594,047)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock and placement agent warrant (in shares)		117,000
Issuance of common stock and placement agent warrant	212,777	$ 11	212,766
Issuance and exercise of pre-funded warrants (in shares)		187,731
Issuance and exercise of pre-funded warrants	1,973,240	$ 19	1,973,221
Reclass warrants to temporary equity	(224,189)		(224,189)
Adjustment due to reverse split	0	$ (2,539)	2,539
Stock-based compensation	348,301		348,301
Net loss	$ (3,077,273)			(3,077,273)
Ending balance (in shares) at Mar. 31, 2024	1,371,051	1,371,051
Ending balance at Mar. 31, 2024	$ 2,742,573	$ 137	$ 228,413,756	$ (225,671,320)

Income Taxes (Detail) - USD ($)	3 Months Ended
Income Taxes (Detail) - USD ($)	Mar. 31, 2024	Mar. 31, 2023
Income Tax Disclosure [Abstract]
Income tax provision (benefit)	$ 0	$ 0
Effective tax rate	0.00%	0.00%

- Definition

Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

+ References + Details

Assets Held For Sale	3 Months Ended
Assets Held For Sale	Mar. 31, 2024
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract]
Assets Held For Sale	Assets Held For Sale On November 29, 2023, the Company and AFAB Lab Resources, LLC (“AFAB”) initiated an asset sales agreement, pursuant to which AFAB would sell certain computers and laboratory. According to Topic 360, the Company determined that the criterion to classify the certain computers and laboratory equipment as assets held for sale within the Company’s balance sheet effective as of March 31, 2024 and December 31, 2023 were met. Accordingly, the assets were classified as current assets held for sale as of March 31, 2024 and December 31, 2023 as the Company, at that time, expected to sell these assets within the next twelve months. The estimated fair value of the computers and laboratory equipment was determined using the purchase price in the purchase agreement along with estimated broker, accounting, legal, and other selling expenses, which resulted in the lower of the carrying value and the fair value less costs to sell of approximately $1.4 million at December 31, 2023. The carrying value of the assets being classified as held for sale was approximately $2.0 million. As a result, the Company recorded a loss on assets held for sale of $0.7 million during the year ended December 31, 2023. Upon completion of the computers and laboratory equipment sales, the Company could record an additional gain or loss on disposal at the time final net proceeds are determined. Additionally, the expected sale of assets held for sale was not deemed to represent a fundamental strategic shift that would have a major effect on the Company’s operations, and accordingly, it was not reported as discontinued operations in the Company’s statement of operations for the year ended December 31, 2023. The fair value of the assets held for sale at March 31, 2024 is approximately $1.0 million. The Company received $0.5 million from the sales of these assets and recognized a gain on sale of these assets of $0.1 million during the three months ended March 31, 2024. There were no assets held for sale and no sales of these assets during the three months ended March 31, 2023.

Net Loss Per Share Attributable to Common Stockholders (Tables)

3 Months Ended

Mar. 31, 2024

Earnings Per Share [Abstract]

Summary of Basic and Diluted Earnings Per Share

The following table sets forth the computation of basic and diluted earnings per share for the three months ended March 31, 2024 and 2023:


	Three Months Ended March 31,
	2024		2023
Net loss	$	(3,077,273)	$	(9,565,077)
Basic and diluted net loss per common share	$	(2.46)	$	(9.17)
Basic and diluted weighted average common shares outstanding	1,250,498		1,043,138

Summary of Antidilutive Securities Outstanding

The following potentially dilutive securities have been excluded from the computation of diluted weighted average common shares outstanding at March 31, 2024 and 2023 as the effect would be anti-dilutive:


	Three Months Ended March 31,
	2024	2023
Warrants	326,062	—
Stock options	119,239	150,789
Restricted stock unit	26,460	61,424
Total	471,761	212,213

Basis of Presentation and Significant Accounting Policies	3 Months Ended
	Mar. 31, 2024
Accounting Policies [Abstract]
Basis of Presentation and Significant Accounting Policies	Basis of Presentation and Significant Accounting Policies The accompanying unaudited financial statements were prepared in accordance with the rules and regulations of the U.S. Securities and Exchange Commission (“SEC”) for interim financial information. Accordingly, they do not include all of the information required by U.S. generally accepted accounting principles (“GAAP”) for complete financial statements. Any reference in these notes to applicable guidance is meant to refer to the authoritative GAAP as found in the ASC and Accounting Standards Updates (“ASU”) of the FASB. These financial statements should be read in conjunction with the audited financial statements and the accompanying notes to the financial statements contained in the Company's Annual Report on Form 10-K for the year ended December 31, 2023, as filed with the SEC on April 16, 2024. In management’s opinion, the accompanying unaudited financial statements contain all adjustments, including normal, recurring adjustments, necessary to fairly present the financial position as of March 31, 2024 and December 31, 2023, and the unaudited statements of operations, statements of changes in stockholders’ equity and statements of cash flows for the three month periods ended March 31, 2024 and 2023. Interim results are not necessarily indicative of results for an entire year. Stock-Based Compensation The Company records compensation expense associated with stock options and other forms of equity compensation based on the estimated fair value at the grant date. Compensation expense related to awards to employees and non-employees with service based vesting conditions is recognized on a straight-line basis based on the grant date fair value over the requisite service period of the award, which is generally the vesting term. The Company’s policy is to account for forfeitures as they occur. The Company uses the Black-Scholes-Merton option pricing ("Black-Scholes"), model to estimate the fair value of stock options. The Black-Scholes model requires input-based assumptions that are highly subjective, judgmental and sensitive in the determination of stock-based compensation cost. Options granted after the Company’s Initial Public Offering ("IPO") are issued at the fair market value of the Common Stock at the date the grant is approved by the Board of Directors. Expected volatility—The expected volatility was based on the historical volatility of comparable public companies from a representative peer group selected based on industry and market capitalization data. The historical volatility is calculated based on a period of time commensurate with the expected term assumption. Risk-free interest rate—The risk-free interest rate was based on the continuous rates provided by the U.S. Treasury with a term approximating the expected term of the option. Expected dividend yield—The expected dividend yield was 0% because the Company has not historically paid and does not expect to pay any dividends for the foreseeable future. Expected term—The Company uses the simplified method as prescribed by the SEC Staff Accounting Bulletin No. 107, Share-Based-Payment, to calculate the expected term for options granted to employees as it does not have sufficient historical exercise data to provide a reasonable basis upon which to estimate the expected term. The Company has used the Monte-Carlo option-pricing model to estimate the fair value of warrants that contain only market conditions. The Monte-Carlo option pricing model uses similar input assumptions as the Black-Scholes model; however, it further incorporates into the fair-value determination the possibility that the market condition may not be satisfied. Derivative Financial Instruments The Company does not use derivative instruments to hedge exposures to cash flow, market, or foreign currency risks. The Company evaluates all of its financial instruments, including units and issued stock purchase warrants, to determine if such instruments are derivatives or contain features that qualify as embedded derivatives, pursuant to ASC 480, “Distinguishing Liabilities from Equity” (“ASC 480”). The classification of derivative instruments, including whether such instruments should be recorded as liabilities or as equity, will be re-assessed at the end of each reporting period. Warrants The Company determines the accounting classification of warrants that are issued, as either liability or equity, by first assessing whether the warrants meet liability classification in accordance with ASC 480-10, Distinguishing Liabilities from Equity, and then in accordance with ASC 815-40, Accounting for Derivative Financial Instruments Indexed to, and Potentially Settled in, a Company’s Own Stock. Under ASC 480-10, warrants are considered liability classified if the warrants are mandatorily redeemable, obligate the issuer to settle the warrants or the underlying shares by paying cash or other assets, or must or may require settlement by issuing variable number of shares. If warrants do not meet liability classification under ASC 480-10, the Company assesses the requirements under ASC 815-40, which states that contracts that require or may require the issuer to settle the contract for cash are liabilities recorded at fair value, irrespective of the likelihood of the transaction occurring that triggers the net cash settlement feature. If the warrants do not require liability classification under ASC 815-40, in order to conclude equity classification, the Company assesses whether the warrants are indexed to its common stock and whether the warrants are classified as equity under ASC 815-40 or other applicable principles of GAAP. After all relevant assessments are made, the Company concludes whether the warrants are classified as liability or equity. Liability classified warrants are required to be accounted for at fair value both on the date of issuance and on subsequent accounting periods with changes in fair value recorded in the Statements of Operations and Comprehensive Loss under "Gain or (loss) on warrant liability". If warrants are issued together with the sale of common stock, for the issuance costs that are not specifically attributed to either the common stock or warrants issued, the Company allocates the issuance costs between the common stock and warrants based on the gross proceeds. The Company expenses issuance costs allocated to the warrants that are classified as liabilities and the issuance costs allocated to common stock or warrants that are classified as equity are recognized as reduction to the equity.

Fair Value Measurements - Summary of Measurement Inputs and Valuation Techniques (Details)	Mar. 31, 2024 $ / shares yr	Feb. 06, 2024 $ / shares yr
Common stock price per share
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Warrants measurement inputs	5.61	10.51
Exercise price per share
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Warrants measurement inputs	12.05	12.05
Expected volatility
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Warrants measurement inputs	1.733	1.760
Risk-free interest rate
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Warrants measurement inputs	0.0460	0.0434
Contractual term (in years)
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Warrants measurement inputs \| yr	1.9	2

Accrued Expenses (Detail) - USD ($)	Mar. 31, 2024	Dec. 31, 2023
Payables and Accruals [Abstract]
Accrued research and development costs	$ 3,224,274	$ 3,148,021
Accrued salaries, benefits and related expenses	306,654	389,858
Accrued professional fees	149,950	131,226
Other accrued expenses	181,816	10,000
Accrued expenses	$ 3,862,694	$ 3,679,105

Pay vs Performance Disclosure - USD ($)	3 Months Ended
Pay vs Performance Disclosure - USD ($)	Mar. 31, 2024	Mar. 31, 2023
Pay vs Performance Disclosure
Net loss	$ (3,077,273)	$ (9,565,077)

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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Reference 2: http://www.xbrl.org/2003/role/disclosureRef
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+ Details

Related Party Transaction	3 Months Ended
Related Party Transaction	Mar. 31, 2024
Related Party Transactions [Abstract]
Related Party Transaction	Related Party Transaction On March 16, 2022, the Company and Zephyr AI, Inc. (“Zephyr”) entered into a Joint Research Agreement (the “JRA”) focused on the joint collaboration, identification and validation of certain targets in order to facilitate further research, development and potential commercialization of immunotherapies. Zephyr is owned by a holding company with multiple Board members from the Company. The JRA term is two years unless mutually extended. As of March 16, 2024, neither party extended the JRA and the JRA expired by its terms. The expenses related to the JRA for the three months ended March 31, 2024 and 2023 were immaterial. Beginning in June 2022, the Company entered into a series of statement of works with the Center for Discovery & Innovation at Hackensack Meridian Health ("CDI") to enhance the Company's AIM platform. The Chairman of the Board of CDI is a Board member. The total value of the statement of work through July 31, 2023 is $0.2 million. The expenses incurred to the CDI for the three months ended March 31, 2024 was $25,000. There were no expenses incurred for the three months ended March 31, 2023. The Company has recorded a $25,000 accrual as of March 31, 2024.

- Definition

The entire disclosure for related party transactions. Examples of related party transactions include transactions between (a) a parent company and its subsidiary; (b) subsidiaries of a common parent; (c) and entity and its principal owners; and (d) affiliates.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (c)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481062/946-235-50-2

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Topic 946
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-Name Accounting Standards Codification
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-Paragraph 2
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-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481062/946-235-50-2

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Topic 850
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-URI https://asc.fasb.org//1943274/2147483326/850-10-50-1

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Topic 946
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-Publisher FASB
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
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Reference 10: http://www.xbrl.org/2003/role/disclosureRef
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Reference 11: http://www.xbrl.org/2003/role/disclosureRef
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Reference 13: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org//1943274/2147483326/850-10-50-1

+ Details

Stock-Based Compensation (Tables)

3 Months Ended

Mar. 31, 2024

Share-Based Payment Arrangement [Abstract]

Stock-Based Compensation Arrangements Repriced Options and Terms

The Nasdaq Stock Market on the Effective Date, which was $0.41 per share (the “Nasdaq Market Price”), on the terms described below:


Repriced Options	Terms of Repriced Options vested or vesting within six months following the Effective Date	Terms of Repriced Options vesting more than six months following the Effective Date
All options held by employees other than our executive officers, in good standing on the Effective Date	The Option Repricing exercise price will be equal to 2.5 times the Nasdaq Market Price, or $25.75.	The Option Repricing exercise price will be equal to the Nasdaq Market Price, or $10.25.
All options held by our current executive officers and 100,000 options held by Jerome Zeldis, our former Executive Vice President and Head of Research & Development	The Option Repricing exercise price will be equal to 3.0 times the Nasdaq Market Price, or $30.75.	The Option Repricing exercise price will be equal to 2.0 times the Nasdaq Market Price, or $20.50.
All options held by our directors	The Option Repricing exercise price will be equal to 4.0 times the Nasdaq Market Price, or $41.00.	The Option Repricing exercise price will be equal to 3.0 times the Nasdaq Market Price, $30.75.

Summary of Stock-Based Compensation Expense

Stock-based compensation expense was recorded in the following financial statement line items within the statement of operations for the periods ended March 31, 2024 and 2023:


	Three Months Ended March 31,
	2024		2023
Research and development expenses	$	74,826	$	259,730
General and administrative expenses	273,475		582,716
Total stock-based compensation expense	$	348,301	$	842,446

Summary of Option Activity

The following is a summary of option activity under the Company’s stock option plans:


	Stock Options	Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (years)	Aggregate Intrinsic Value (in millions)
Outstanding as of January 1, 2024	130,526	$	28.64	7.3	$	—
Granted	—	—
Exercised	—	—
Cancelled	(11,287)	21.50
Forfeited	—	—
Outstanding as of March 31, 2024	119,239	$	29.32	7.2	$	—
Vested or expected to vest as of March 31, 2024	119,239	$	29.32	7.2	—
Exercisable as of March 31, 2024	72,030	$	39.37	6.1	—
Shares unvested as of March 31, 2024	47,209	$	13.99	8.6	$	—

Schedule of Unvested Restricted Stock Units Roll Forward

The following is a summary of RSU activity for the 2021 Plan for the three months ended March 31, 2024:


	Number of restricted units	Weighted average grant date fair value
Unvested and outstanding at January 1, 2023	26,460	$	11.36
Granted	—	—
Settled	—	—
Forfeited	—	—
Unvested and outstanding as of March 31, 2024	26,460	$	11.36

Fair Value Measurements

3 Months Ended

Mar. 31, 2024

Fair Value Disclosures [Abstract]

Fair Value Measurements

The Company’s financial instruments include cash, cash equivalents, warrant liabilities, accounts payable and accrued expenses. The fair values of the cash, cash equivalents, accounts payable and accrued expenses approximated their carrying values as of March 31, 2024 and December 31, 2023 due to their short-term maturities.

The Company accounts for recurring and nonrecurring fair value measurements in accordance with ASC 820, Fair Value Measurements (“ASC 820”). ASC 820 defines fair value, establishes a fair value hierarchy for assets and liabilities measured at fair value, and requires expanded disclosures about fair value measurements. The ASC hierarchy ranks the quality of reliability of inputs, or assumptions, used in the determination of fair value, and requires assets and liabilities carried at fair value to be classified and disclosed in one of the following three categories:

Level 1 -Fair value is determined by using unadjusted quoted prices that are available in active markets for identical assets and liabilities.

Level 2 -Fair value is determined by using inputs, other than Level 1 quoted prices that are directly and indirectly observable. Inputs can include quoted prices for similar assets and liabilities in active markets or quoted prices for identical assets and liabilities in inactive markets. Related inputs can also include those used in valuation or other pricing models that can be corroborated by observable market data.

Level 3 -Fair value is determined by inputs that are unobservable and not corroborated by market data. Use of these inputs involves significant judgments to be made by a reporting entity.

In instances where the determination of the fair value measurement is based on inputs from different levels of fair value hierarchy, the fair value measurement will fall within the lowest level input that is significant to the fair value measurement in its entirety. The Company periodically evaluates financial assets and liabilities subject to fair value measurements to determine the appropriate level at which to classify them each reporting period. This determination requires the Company to make judgments as to the significance of inputs used in determining fair value and where such inputs lie within the ASC 820 hierarchy.

The following table represents the Company’s fair value hierarchy for its financial assets measured at fair value on a recurring basis:


	March 31, 2024						December 31, 2023
	Level 1		Level 2		Level 3		Level 1		Level 2		Level 3
Assets
Money market funds	$	23,454	$	—	$	—	$	23,270	$	—	$	—

	$	23,454	$	—	$	—	$	23,270	$	—	$	—
Liabilities
Warrant liability	—		—		1,389,543		—		—		—
	$	—	$	—	$	1,389,543	$	—	$	—	$	—

As of March 31, 2024, warrants representing 304,731 shares of Common Stock issued in the February 2024 Offerings were outstanding. All of these warrants are classified as a liability and are measured at fair value. Each quarter, the Company expects an impact on our statement of operations when the change in fair value of our outstanding warrants is recorded using the Monte Carlo pricing model, based on significant inputs not observable in the market, which represents a Level 3 measurement. The Company used the following key assumptions within its valuation. In all scenarios, the Company also applied the likelihood of a fundamental transaction and the related impact on the Common Stock price and volatility.


	February 6, 2024			March 31, 2024
Common stock price per share	$	10.51		$	5.61
Exercise price per share	$	12.05		$	12.05
Expected volatility	176.0		%	173.3		%
Risk-free interest rate	4.34		%	4.60		%
Contractual term (in years)	2			1.9

The following is a roll forward of the fair value of Level 3 warrants:


	Warrant Liability Fair Value
Balance as of December 31, 2023	$	—
Warrants issued	2,810,382
Change in fair value	(1,420,839)
Balance as of March 31, 2024	$	1,389,543

- Definition

The entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.

+ References + Details

Property and Equipment - Additional Information (Detail) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Property, Plant and Equipment [Abstract]
Depreciation and amortization	$ 0.1	$ 0.3

STATEMENTS OF OPERATIONS (UNAUDITED) - USD ($)	3 Months Ended
STATEMENTS OF OPERATIONS (UNAUDITED) - USD ($)	Mar. 31, 2024	Mar. 31, 2023
Operating expenses:
Research and development	$ 744,023	$ 6,124,044
General and administrative	2,013,443	3,701,365
Total operating expenses	2,757,466	9,825,409
Loss from operations	(2,757,466)	(9,825,409)
Other income (expense):
Interest income	14,790	274,738
Change in fair value of warrant liability	1,420,839	0
Loss on issuance of common stock and warrants	(1,111,614)	0
Offering costs	(740,836)	0
Other income (expense)	97,014	(14,406)
Other income, net	(319,807)	260,332
Net loss	$ (3,077,273)	$ (9,565,077)
Basic net loss per common share (in dollars per share)	$ (2.46)	$ (9.17)
Diluted net loss per common share (in dollars per share)	$ (2.46)	$ (9.17)
Basic weighted average number of common shares outstanding (in shares)	1,250,498	1,043,138
Diluted weighted-average number of common shares outstanding (in shares)	1,250,498	1,043,138

Subsequent Events	3 Months Ended
Subsequent Events	Mar. 31, 2024
Subsequent Events [Abstract]
Subsequent Events	16. Subsequent Events Not applicable

Net Loss Per Share Attributable to Common Stockholders

3 Months Ended

Mar. 31, 2024

Earnings Per Share [Abstract]

Net Loss Per Share Attributable to Common Stockholders

Basic net loss per common share is determined by dividing net loss attributable to common stockholders by the weighted-average number of common shares outstanding during the period, without consideration of common stock equivalents. Diluted net loss per share is computed by dividing net loss attributable to common stockholders by the weighted-average number of Common Stock and Common Stock equivalents outstanding for the period. The treasury stock method is used to determine the dilutive effect of the Company’s stock option, RSU and warrant grants and the if-converted method is used to determine the dilutive effect of the Company’s contingently redeemable warrants. Under the if-converted method, contingently redeemable warrants that are in the money, are assumed to have been converted as of the beginning of the period or when issued, if later. None of the contingently redeemable warrants were in the money at March 31, 2024. For the three months ended March 31, 2024 and 2023, the Company had a net loss attributable to common stockholders, and as such, all outstanding stock options, RSUs and warrants were anti-dilutive.

The following table sets forth the computation of basic and diluted earnings per share for the three months ended March 31, 2024 and 2023:


	Three Months Ended March 31,
	2024		2023
Net loss	$	(3,077,273)	$	(9,565,077)
Basic and diluted net loss per common share	$	(2.46)	$	(9.17)
Basic and diluted weighted average common shares outstanding	1,250,498		1,043,138


	Three Months Ended March 31,
	2024	2023
Warrants	326,062	—
Stock options	119,239	150,789
Restricted stock unit	26,460	61,424
Total	471,761	212,213

Prepaid Expenses And Other Current Assets (Detail) - USD ($)	Mar. 31, 2024	Dec. 31, 2023
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract]
Prepaid research and development expenses	$ 121,385	$ 115,353
Prepaid insurance	313,859	368,048
Prepaid other	87,636	35,817
Other current assets	66,330	215,246
Total prepaid expenses and other current assets	$ 589,210	$ 734,464

Basis of Presentation and Significant Accounting Policies - Narrative (Detail)	3 Months Ended
	Mar. 31, 2024
Stock options
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Expected dividend yield	0.00%

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 35
-Paragraph 1D
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480483/718-10-35-1D

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
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-Section 35
-Paragraph 3
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-URI https://asc.fasb.org//1943274/2147480483/718-10-35-3

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
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-Name Accounting Standards Codification
-Section 50
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-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480429/718-10-50-2

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
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-Subparagraph (a)(2)
-Publisher FASB
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Reference 5: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org//1943274/2147480429/718-10-50-2

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
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Reference 7: http://www.xbrl.org/2003/role/disclosureRef
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Reference 9: http://www.xbrl.org/2003/role/disclosureRef
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Reference 10: http://www.xbrl.org/2003/role/disclosureRef
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Reference 11: http://www.xbrl.org/2003/role/disclosureRef
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Reference 12: http://www.xbrl.org/2003/role/disclosureRef
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Reference 13: http://www.xbrl.org/2003/role/disclosureRef
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Reference 14: http://www.xbrl.org/2003/role/disclosureRef
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Reference 28: http://www.xbrl.org/2003/role/disclosureRef
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-Section 50
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-Subparagraph (f)(2)(v)
-Publisher FASB
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+ Details

Cash, Cash Equivalents, and Restricted Cash

3 Months Ended

Mar. 31, 2024

Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents [Abstract]

Cash, and Cash Equivalents, and Restricted Cash

Cash, Cash Equivalents, and Restricted Cash

The following table presents the Company’s cash, cash equivalents and restricted cash as of March 31, 2024 and December 31, 2023:


	March 31, 2024		December 31, 2023
Cash and cash equivalents:
Cash and cash equivalents	$	4,452,898	$	3,202,452



Restricted cash	20,000		20,000
Total cash, cash equivalents, and restricted cash	$	4,472,898	$	3,222,452

The Company considers all investments in highly liquid financial instruments with an original maturity of ninety days or less at the date of purchase to be cash equivalents. Cash equivalents are stated at amortized cost, plus accrued interest, which approximates fair value.

Amounts included in restricted cash represent those required as collateral on corporate credit cards.

Prepaid Expenses and Other Current Assets (Tables)

3 Months Ended

Mar. 31, 2024

Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract]

Summary of Prepaid Expenses and Other Current Assets

Prepaid expenses and other current assets consist of the following at March 31, 2024 and December 31, 2023:


	March 31, 2024		December 31, 2023
Prepaid research and development expenses	$	121,385	$	115,353

Prepaid insurance	313,859		368,048
Prepaid other	87,636		35,817

Other current assets	66,330		215,246
Total prepaid expenses and other current assets	$	589,210	$	734,464

Stockholders’ Equity and Contingently Redeemable Warrants	3 Months Ended
	Mar. 31, 2024
Stockholders' Equity Note [Abstract]
Stockholders’ Equity and Contingently Redeemable Warrants	Stockholders’ Equity and Contingently Redeemable Warrants The Company had 250,000,000 authorized shares of Common Stock, of which 1,371,051 and 1,066,320 shares were issued and outstanding at March 31, 2024 and December 31, 2023, respectively. Issuances of Common Stock On March 9, 2022, the Company filed a shelf registration statement on Form S-3 ("Form S-3") with the SEC pursuant to which we disclosed that we may offer and sell, from time to time in one or more offerings, any combination of common stock, preferred stock, debt securities, warrants, rights or units having a maximum aggregate offering price of $200 million. On June 17, 2022, the Company entered into a Controlled Equity Offering Sales Agreement (the “Sales Agreement”) with Cantor Fitzgerald & Co. and BTIG, LLC (together, the “Agents”), pursuant to which the Company may offer and sell shares of the Common Stock at an aggregate offering price of up to $50.0 million from time to time through the Agents. Subject to the terms and conditions of the Sales Agreement, any such sales made through the Agents can be made, based upon the Company's instructions, by methods deemed an “at-the-market” offering as defined in Rule 415(a)(4) promulgated under the Securities Act. The Company agreed to pay the Agents a commission of 3.0% of the gross proceeds of any sales of shares sold pursuant to the Sales Agreement. No sales were transacted for the three months ended March 31, 2024 and year ended December 31, 2023. On February 2, 2024, the Company and each of the Agents mutually agreed to terminate the Sales Agreement effective immediately. The Company did not incur any material early termination penalties in connection with the termination of the Sales Agreement. On February 2, 2024, the Company, entered into the Purchase Agreement with the Investor pursuant to which the Company agreed to issue and sell in the Registered Offering, (i) an aggregate of 117,000 Shares of Common Stock at an offering price of $12.05 per share, and (ii) Pre-Funded Warrants exercisable for up to 187,731 shares of Common Stock at an offering price of $12.049 per Pre-Funded Warrant, for aggregate gross proceeds from the February 2024 Offerings of approximately $3.7 million before deducting the placement agent fee and related offering expenses of approximately $0.5 million. Since the fair value of the liabilities for the Pre-Funded Warrant, Unregistered Warrant, and Unregistered PA Warrant were greater than the gross proceeds received from the February 2024 Offerings, the Company recorded a $1.1 million loss on issuance of common stock and warrants. All of the placement agent fees and related offering expenses of $0.5 million was therefore allocated to the warrant liabilities and expensed. The fair value of the Unregistered PA warrants of approximately $0.2 million was also allocated to the warrant liabilities and expensed. The shares of Common Stock and Pre-Funded Warrants (and shares of Common Stock underlying the Pre-Funded Warrants) were offered by the Company pursuant to its shelf registration statement on Form S-3 (File No. 333-263399), which was filed with the SEC on March 9, 2022 and declared effective by the SEC on March 16, 2022 (“Registration Statement”), including the base prospectus contained therein, and a related prospectus supplement, dated February 2, 2024, filed with the SEC on February 5, 2024. All of the Pre-Funded Warrants were exercised at closing. In the Private Placement, the Company issued to the Investor unregistered warrants to purchase up to an aggregate of 304,731 Unregistered Warrants at an exercise price of $12.05 per share. Each Unregistered Warrant is exercisable immediately and will expire two years from the initial exercise date. The Company also issued to the placement agent unregistered warrants to purchase up to an aggregate of 21,331 shares of Common Stock (the “Unregistered PA Warrants”) at an exercise price of $15.0625 per share. Each Unregistered PA Warrant is exercisable immediately and will expire five years from the initial exercise date. The Unregistered Warrants and Unregistered PA Warrants and the shares of our Common Stock issuable upon the exercise of the Unregistered Warrants and Unregistered PA Warrants are not being registered under the Securities Act of 1933, as amended (the “Securities Act”), are not being offered pursuant to the Registration Statement and are being offered pursuant to the exemption provided in Section 4(a)(2) under the Securities Act, and/or Rule 506(b) promulgated thereunder. The Unregistered Warrants are classified as a liability in accordance with ASC 480 and ASC 815. The Company evaluated the Unregistered Warrants under ASC 815-40 and concluded that they do not meet the criteria to be classified in stockholders’ equity. Specifically, the settlement value in a scenario of a fundamental transaction precluded the Unregistered Warrants from being indexed to the Company’s own stock and Company believes that the scope exception related to the occurrence of a fundamental transaction in ASC 815-40 is not met. Since the Unregistered Warrants meet the definition of a derivative, they are recorded as liabilities and measured at fair value at initial recognition. Any subsequent changes in their respective fair values is recognized in the Statement of Operations at each reporting date. These warrant agreements include a fundamental transaction clause whereby, in the event that another person or entity becomes the beneficial owner of 50% of the outstanding shares of the Common Stock, and if other conditions are met, the Company may be required to purchase the warrants from the holders by paying cash in an amount equal to the Black-Scholes value of the remaining unexercised portion of the warrants on the date of such fundamental transaction. The warrants were recorded at their fair value of $2.8 million at issuance based on a Monte Carlo simulation. The Pre-Funded Warrants were initially classified as a liability in accordance with ASC 815, since these warrants can be settled in cash or other assets and therefore did not qualify for equity classification. The Pre-Funded Warrants were recorded at their fair value of $2.0 million at issuance based on the Company's stock price at closing. All of the Pre-Funded Warrants were exercised at closing and therefore reclassifed to stockholders' equity. The Unregistered PA Warrants are classified as a contingently redeemable warrant in accordance with ASC 718, since these warrants did qualify for equity classification, but could be settled in cash or other assets. These warrant agreements include a fundamental transaction clause whereby, in the event that another person or entity becomes the beneficial owner of 50% of the outstanding shares of the Company's common stock, and if other conditions are met, the Company may be required to purchase the warrants from the holders by paying cash in an amount equal to the Black-Scholes value of the remaining unexercised portion of the warrants on the date of such fundamental transaction. Because this contingently redeemable feature could result in the warrant holders receiving additional compensation not on par with the holders of Common Stock, the PA Warrants were classified within temporary equity. The warrants were recorded at their fair value of $0.2 million at issuance based on a Monte Carlo simulation. Inherent in a Monte Carlo simulation are various assumptions as follows: stock price of $10.51, exercise price of $15.06, expected stock-price volatility of 152.0%, contractual life of 5.0 years, risk-free interest rate of 3.99% and dividend yield of 0%.

- Definition

The entire disclosure for equity.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-13

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org//1943274/2147481112/505-10-50-13

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
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-Paragraph 14
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-14

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
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-Subparagraph (a)
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-URI https://asc.fasb.org//1943274/2147481062/946-235-50-2

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
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-Paragraph 2
-Subparagraph (d)
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-URI https://asc.fasb.org//1943274/2147481062/946-235-50-2

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
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-URI https://asc.fasb.org//1943274/2147481004/946-505-50-6

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
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Reference 9: http://www.xbrl.org/2003/role/disclosureRef
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-Paragraph 1
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Reference 10: http://fasb.org/us-gaap/role/ref/legacyRef
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-URI https://asc.fasb.org//505/tableOfContent

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
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Reference 12: http://www.xbrl.org/2003/role/disclosureRef
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Reference 13: http://www.xbrl.org/2003/role/disclosureRef
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-Paragraph 13
-Subparagraph (i)
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-URI https://asc.fasb.org//1943274/2147481112/505-10-50-13

Reference 14: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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-Name Accounting Standards Codification
-Section 50
-Paragraph 14
-Subparagraph (a)
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Reference 15: http://www.xbrl.org/2003/role/disclosureRef
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Reference 16: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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Reference 17: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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-Subparagraph (a)
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Reference 18: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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-Name Accounting Standards Codification
-Section 50
-Paragraph 18
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-18

Reference 19: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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-Section 50
-Paragraph 18
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-18

+ Details

BALANCE SHEETS - USD ($)	Mar. 31, 2024	Dec. 31, 2023
Current assets:
Cash and cash equivalents	$ 4,452,898	$ 3,202,452
Restricted cash	20,000	20,000
Assets held for sale	979,915	1,444,043
Prepaid expenses and other current assets	589,210	734,464
Total current assets	6,042,023	5,400,959
Property and equipment, net	1,237,989	1,352,901
Operating lease right-of-use assets	0	46,716
Other non-current assets	1,710,601	1,793,373
Total assets	8,990,613	8,593,949
Current liabilities:
Accounts payable	771,614	1,336,318
Accrued expenses	3,862,694	3,679,105
Operating lease liabilities, current	0	68,809
Total current liabilities	4,634,308	5,084,232
Warrant liability	1,389,543	0
Total liabilities	6,023,851	5,084,232
Commitments and contingencies
Contingently redeemable warrants	224,189	0
Stockholders’ equity
Common Stock, $0.0001 par value per share, 250,000,000 shares authorized as of March 31, 2024 and December 31, 2023; 1,371,051 and 1,066,320 shares issued and outstanding as of March 31, 2024 and December 31, 2023, respectively.	137	2,646
Additional paid-in-capital	228,413,756	226,101,118
Accumulated deficit	(225,671,320)	(222,594,047)
Total stockholders’ equity	2,742,573	3,509,717
Total liabilities and stockholders’ equity	$ 8,990,613	$ 8,593,949

Stock-Based Compensation

3 Months Ended

Mar. 31, 2024

Share-Based Payment Arrangement [Abstract]

Stock-Based Compensation

During January 2017, the Company adopted the 2017 Equity Incentive Plan (“2017 Plan”), which provides for the granting of restricted stock, options to purchase shares of Common Stock and other awards to employees, directors and consultants. In March 2017, the Company amended the 2017 Plan to increase the number of available shares to 26,433. In September 2018, the Company adopted the 2018 Equity Incentive Plan (“2018 Plan”) which provides for the granting of restricted stock, options to purchase shares of Common Stock, and other awards to employees, directors and consultants, and reserved 69,670 shares for this purpose. The 2018 Plan was amended in July 2018 to increase the number of available shares to 72,365 shares. In February 2021, the Company adopted the 2021 Equity Incentive Plan (“2021 Plan”) and no further shares will be issued under the 2017 and 2018 plans. There are 150,944 shares available for issuance under the 2021 plan as of March 31, 2024.

The number of options to be granted under the 2021 Plan, the option exercise prices, and other terms of the options are determined by the Board in accordance with the terms of the 2021 Plan. Generally, stock options are granted at fair value, become exercisable over a period of one to four years, expire in ten years or less and are subject to the employee’s continued employment. Restricted stock units awarded in November 2022 vest after an 18-month service period. No restricted stock units were awarded in the three months ended March 31, 2024.

On March 22, 2023, in order to retain and motivate employees and other key contributors of the Company, the Board approved a one-time stock option repricing (the “Option Repricing”). Pursuant to the Option Repricing, the exercise price of all of the below stock options to purchase shares of the Common Stock previously granted under our 2017 Plan, 2018 Plan and 2021 Plan (the “Repriced Options”) was amended as of April 4, 2023 (the “Effective Date”) to reduce the exercise prices of

such options to a price equal to or greater than the closing price per share of the Common Stock on The Nasdaq Stock Market on the Effective Date, which was $0.41 per share (the “Nasdaq Market Price”), on the terms described below:


Repriced Options	Terms of Repriced Options vested or vesting within six months following the Effective Date	Terms of Repriced Options vesting more than six months following the Effective Date
All options held by employees other than our executive officers, in good standing on the Effective Date	The Option Repricing exercise price will be equal to 2.5 times the Nasdaq Market Price, or $25.75.	The Option Repricing exercise price will be equal to the Nasdaq Market Price, or $10.25.
All options held by our current executive officers and 100,000 options held by Jerome Zeldis, our former Executive Vice President and Head of Research & Development	The Option Repricing exercise price will be equal to 3.0 times the Nasdaq Market Price, or $30.75.	The Option Repricing exercise price will be equal to 2.0 times the Nasdaq Market Price, or $20.50.
All options held by our directors	The Option Repricing exercise price will be equal to 4.0 times the Nasdaq Market Price, or $41.00.	The Option Repricing exercise price will be equal to 3.0 times the Nasdaq Market Price, $30.75.

The Company treated the Option Repricing as a modification to the original stock option grant because the terms of the agreements were modified. The total number of options issued and outstanding were not impacted by the Option Repricing.

The calculation of the incremental compensation expense is based on the excess of the fair value of the award measured immediately before and after the modification. The total incremental expense calculated to be recognized over the service period is $0.3 million.

Stock-based compensation expense was recorded in the following financial statement line items within the statement of operations for the periods ended March 31, 2024 and 2023:


	Three Months Ended March 31,
	2024		2023
Research and development expenses	$	74,826	$	259,730
General and administrative expenses	273,475		582,716
Total stock-based compensation expense	$	348,301	$	842,446

The following is a summary of option activity under the Company’s stock option plans:


	Stock Options	Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (years)	Aggregate Intrinsic Value (in millions)
Outstanding as of January 1, 2024	130,526	$	28.64	7.3	$	—
Granted	—	—
Exercised	—	—
Cancelled	(11,287)	21.50
Forfeited	—	—
Outstanding as of March 31, 2024	119,239	$	29.32	7.2	$	—
Vested or expected to vest as of March 31, 2024	119,239	$	29.32	7.2	—
Exercisable as of March 31, 2024	72,030	$	39.37	6.1	—
Shares unvested as of March 31, 2024	47,209	$	13.99	8.6	$	—

There were no options granted during the three months ended March 31, 2024 and 2023. No options were exercised in the three months ended March 31, 2024 and 2023.

As of March 31, 2024, there was $1.6 million of total unrecognized compensation expense related to unvested options that will be recognized over a weighted average period of 1.7 years.

Restricted Stock Units

A restricted stock unit (“RSU”) represents the right to receive one of the Common Stock upon vesting of the RSU. The fair value of each RSU is based on the closing price of the Common Stock on the date of grant.

The following is a summary of RSU activity for the 2021 Plan for the three months ended March 31, 2024:


	Number of restricted units	Weighted average grant date fair value
Unvested and outstanding at January 1, 2023	26,460	$	11.36
Granted	—	—
Settled	—	—
Forfeited	—	—
Unvested and outstanding as of March 31, 2024	26,460	$	11.36

As of March 31, 2024, there was $37,441 of unrecognized compensation expense related to unvested RSUs, which are expected to be recognized over a weighted average period of 0.15 years.

STATEMENTS OF OPERATIONS (UNAUDITED) (Parenthetical)	Oct. 18, 2023
Income Statement [Abstract]
Reverse stock split, conversion ratio	0.04

Cover - shares	3 Months Ended
Cover - shares	Mar. 31, 2024	May 15, 2024
Cover [Abstract]
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Mar. 31, 2024
Document Transition Report	false
Entity File Number	001-40045
Entity Registrant Name	NEXIMMUNE, INC.
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	42-2518457
Entity Address, Address Line One	9119 Gaither Road
Entity Address, City or Town	Gaithersburg,
Entity Address, State or Province	MD
Entity Address, Postal Zip Code	20877
City Area Code	301
Local Phone Number	825-9810
Title of 12(b) Security	Common Stock, $0.0001 par value per share
Trading Symbol	NEXI
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	true
Entity Ex Transition Period	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		1,371,051
Amendment Flag	false
Current Fiscal Year End Date	--12-31
Document Fiscal Period Focus	Q1
Document Fiscal Year Focus	2024
Entity Central Index Key	0001538210

Net Loss Per Share Attributable to Common Stockholders - Summary of Antidilutive Securities Outstanding (Detail) - shares	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Potentially dilutive securities (in shares)	471,761	212,213
Contingently redeemable warrants
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Potentially dilutive securities (in shares)	326,062	0
Stock options
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Potentially dilutive securities (in shares)	119,239	150,789
Restricted stock unit
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Potentially dilutive securities (in shares)	26,460	61,424

Restructuring Activities - Additional Information (Details) $ in Millions	1 Months Ended
	Aug. 31, 2023 USD ($) employee	Nov. 30, 2022 USD ($) employee
Restructuring and Related Activities [Abstract]
Expected number of positions eliminated, percent		30.00%
Number of positions before eliminations \| employee	44	74
Number of positions after eliminations \| employee	6	50
Restructuring cost, reduction in workforce \| $		$ 0.7
Restructuring cost, cost incurred to date \| $	$ 3.1

Cash, Cash Equivalents, and Restricted Cash (Tables)

3 Months Ended

Mar. 31, 2024

Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents [Abstract]

Summary of Reconciliation of Cash and Cash Equivalents

The following table presents the Company’s cash, cash equivalents and restricted cash as of March 31, 2024 and December 31, 2023:


	March 31, 2024		December 31, 2023
Cash and cash equivalents:
Cash and cash equivalents	$	4,452,898	$	3,202,452



Restricted cash	20,000		20,000
Total cash, cash equivalents, and restricted cash	$	4,472,898	$	3,222,452

Stock-Based Compensation - Summary of Stock Based Compensation Expense (Detail) - USD ($)	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Stock-based compensation expense	$ 348,301	$ 842,446
Research and development expenses
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Stock-based compensation expense	74,826	259,730
General and administrative expenses
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Stock-based compensation expense	$ 273,475	$ 582,716

Commitments and Contingencies (Detail) - USD ($)	1 Months Ended	3 Months Ended		12 Months Ended
Commitments and Contingencies (Detail) - USD ($)	Jan. 31, 2017	Mar. 31, 2024	Mar. 31, 2023	Dec. 31, 2013	Dec. 31, 2023
Accrued royalties		$ 75,000			$ 50,000
Loss contingency accrual		0			$ 0
Research and development expenses
Royalty expense		25,000	$ 25,000
Maryland Biotechnology Center \| Translational Research Award Agreement
Research and development arrangement contract to perform for others liability		0		$ 325,000
Research and development arrangement annual payment percentage				3.00%
Research and development arrangement contractual payment period				10 years
Research and development arrangement contractual payment percentage				200.00%
Revenue from contract with customer, including assessed tax		0
Johns Hopkins University \| Exclusive License Agreement
Milestone fees	$ 4,200,000
Minimum annual royalty payments	$ 100,000	100,000
Maximum non-royalty sublicense payments, percent	15.00%
Cumulative minimum royalties		$ 650,000
Johns Hopkins University \| Exclusive License Agreement \| Clinical Trial Milestones
Milestone fees	$ 75,000
Johns Hopkins University \| Exclusive License Agreement \| Therapeutic Field
Milestone fees	1,600,000
Johns Hopkins University \| Exclusive License Agreement \| Regulatory and Commercial Milestones
Milestone fees	400,000
Johns Hopkins University \| Exclusive License Agreement \| Non-clinical field
Milestone fees	$ 100,000

Restructuring Activities

3 Months Ended

Mar. 31, 2024

Restructuring and Related Activities [Abstract]

Restructuring Activities

In November 2022, the Company announced that, following a strategic review of its pipeline, indications, timelines and cash position, it implemented a strategic realignment initiative, which was designed to reduce costs and reallocate resources towards its AIM INJ preclinical development programs. The Company initiated a workforce reduction plan to reduce headcount by 30%, primarily affecting the clinical development, manufacturing and administrative staff that had been needed to support the AIM Adoptive Cellular Therapy ("ACT") clinical programs. The plan reduced the Company’s workforce from 74 full-time employees to approximately 50 full-time employees. The Company incurred $0.7 million of costs in connection with the reduction in workforce related to severance pay and other related termination benefits. These one-time employee termination benefits are comprised of severance, benefits and related costs, all of which are expected to result in cash expenditures.

In August and November 2023, the Company announced that, in order to reduce its cash expenditures while continuing to pursue its existing strategic plan, the Board approved and its management is implementing a reduction in workforce, designed to reduce costs and extend the Company’s cash. The realignment reduced the Company’s workforce from 44 to 6 full-time employees. The Company incurred $3.1 million of costs in connection with the reduction in workforce related to severance pay and other related termination benefits. These one-time employee termination benefits are comprised of severance, benefits and related costs, all of which are expected to result in cash expenditures. The Company expects that the payments for the reduction-in-force will be substantially complete in September 2024.

The following table summarizes the charges related to the restructuring activities as of March 31, 2024.


	Accrued Restructuring Expenses						Accrued Restructuring Expenses
	December 31, 2023		Expenses		Less: Payments		March 31, 2024
Severance, benefits and related costs due to workforce reduction	$	266,537	$	—	$	(26,470)	$	240,067
Totals	$	266,537	$	—	$	(26,470)	$	240,067

Income Taxes	3 Months Ended
Income Taxes	Mar. 31, 2024
Income Tax Disclosure [Abstract]
Income Taxes	Income Taxes The Company has not recorded any tax provision or benefit for the three months ended March 31, 2024 and 2023. The Company has provided a valuation allowance for the full amount of its net deferred tax assets since realization of any future benefit from deductible temporary differences, net operating loss carryforwards, and research and development credits is not more-likely-than-not to be realized at March 31, 2024 and December 31, 2024. The effective tax rate for each of the three months ended March 31, 2024 and 2023 is 0%.

- Definition

The entire disclosure for income taxes. Disclosures may include net deferred tax liability or asset recognized in an enterprise's statement of financial position, net change during the year in the total valuation allowance, approximate tax effect of each type of temporary difference and carryforward that gives rise to a significant portion of deferred tax liabilities and deferred tax assets, utilization of a tax carryback, and tax uncertainties information.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 946
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480990/946-20-50-13

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 235
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08(h)(2))
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480678/235-10-S99-1

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-Name Accounting Standards Codification
-Publisher FASB
-URI https://asc.fasb.org//740/tableOfContent

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 14
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-URI https://asc.fasb.org//1943274/2147482685/740-10-50-14

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+ Details

Restructuring Activities (Tables)

3 Months Ended

Mar. 31, 2024

Restructuring and Related Activities [Abstract]

Summary of Charges Related to Restructuring Activities

The following table summarizes the charges related to the restructuring activities as of March 31, 2024.


	Accrued Restructuring Expenses						Accrued Restructuring Expenses
	December 31, 2023		Expenses		Less: Payments		March 31, 2024
Severance, benefits and related costs due to workforce reduction	$	266,537	$	—	$	(26,470)	$	240,067
Totals	$	266,537	$	—	$	(26,470)	$	240,067

Stock-Based Compensation - Summary of RSU Activity (Details) - Restricted stock unit	3 Months Ended
	Mar. 31, 2024 $ / shares shares
Number of restricted units
Beginning balance (in shares) \| shares	26,460
Granted (in shares) \| shares	0
Settled (in shares) \| shares	0
Forfeited (in shares) \| shares	0
Ending balance (in shares) \| shares	26,460
Weighted Average Exercise Price
Beginning balance (in dollars per share) \| $ / shares	$ 11.36
Granted (in dollars per share) \| $ / shares	0
Settled (in dollars per share) \| $ / shares	0
Forfeited (in dollars per share) \| $ / shares	0
Ending balance (in dollars per share) \| $ / shares	$ 11.36

Basis of Presentation and Significant Accounting Policies (Policies)	3 Months Ended
	Mar. 31, 2024
Accounting Policies [Abstract]
Basis of Presentation	The accompanying unaudited financial statements were prepared in accordance with the rules and regulations of the U.S. Securities and Exchange Commission (“SEC”) for interim financial information. Accordingly, they do not include all of the information required by U.S. generally accepted accounting principles (“GAAP”) for complete financial statements. Any reference in these notes to applicable guidance is meant to refer to the authoritative GAAP as found in the ASC and Accounting Standards Updates (“ASU”) of the FASB.
Derivative Financial Instruments	Derivative Financial Instruments The Company does not use derivative instruments to hedge exposures to cash flow, market, or foreign currency risks. The Company evaluates all of its financial instruments, including units and issued stock purchase warrants, to determine if such instruments are derivatives or contain features that qualify as embedded derivatives, pursuant to ASC 480, “Distinguishing Liabilities from Equity” (“ASC 480”). The classification of derivative instruments, including whether such instruments should be recorded as liabilities or as equity, will be re-assessed at the end of each reporting period. Warrants The Company determines the accounting classification of warrants that are issued, as either liability or equity, by first assessing whether the warrants meet liability classification in accordance with ASC 480-10, Distinguishing Liabilities from Equity, and then in accordance with ASC 815-40, Accounting for Derivative Financial Instruments Indexed to, and Potentially Settled in, a Company’s Own Stock. Under ASC 480-10, warrants are considered liability classified if the warrants are mandatorily redeemable, obligate the issuer to settle the warrants or the underlying shares by paying cash or other assets, or must or may require settlement by issuing variable number of shares. If warrants do not meet liability classification under ASC 480-10, the Company assesses the requirements under ASC 815-40, which states that contracts that require or may require the issuer to settle the contract for cash are liabilities recorded at fair value, irrespective of the likelihood of the transaction occurring that triggers the net cash settlement feature. If the warrants do not require liability classification under ASC 815-40, in order to conclude equity classification, the Company assesses whether the warrants are indexed to its common stock and whether the warrants are classified as equity under ASC 815-40 or other applicable principles of GAAP. After all relevant assessments are made, the Company concludes whether the warrants are classified as liability or equity. Liability classified warrants are required to be accounted for at fair value both on the date of issuance and on subsequent accounting periods with changes in fair value recorded in the Statements of Operations and Comprehensive Loss under "Gain or (loss) on warrant liability". If warrants are issued together with the sale of common stock, for the issuance costs that are not specifically attributed to either the common stock or warrants issued, the Company allocates the issuance costs between the common stock and warrants based on the gross proceeds. The Company expenses issuance costs allocated to the warrants that are classified as liabilities and the issuance costs allocated to common stock or warrants that are classified as equity are recognized as reduction to the equity.
Fair Value Measurement	The Company’s financial instruments include cash, cash equivalents, warrant liabilities, accounts payable and accrued expenses. The fair values of the cash, cash equivalents, accounts payable and accrued expenses approximated their carrying values as of March 31, 2024 and December 31, 2023 due to their short-term maturities. The Company accounts for recurring and nonrecurring fair value measurements in accordance with ASC 820, Fair Value Measurements (“ASC 820”). ASC 820 defines fair value, establishes a fair value hierarchy for assets and liabilities measured at fair value, and requires expanded disclosures about fair value measurements. The ASC hierarchy ranks the quality of reliability of inputs, or assumptions, used in the determination of fair value, and requires assets and liabilities carried at fair value to be classified and disclosed in one of the following three categories: Level 1 -Fair value is determined by using unadjusted quoted prices that are available in active markets for identical assets and liabilities. Level 2 -Fair value is determined by using inputs, other than Level 1 quoted prices that are directly and indirectly observable. Inputs can include quoted prices for similar assets and liabilities in active markets or quoted prices for identical assets and liabilities in inactive markets. Related inputs can also include those used in valuation or other pricing models that can be corroborated by observable market data. Level 3 -Fair value is determined by inputs that are unobservable and not corroborated by market data. Use of these inputs involves significant judgments to be made by a reporting entity. In instances where the determination of the fair value measurement is based on inputs from different levels of fair value hierarchy, the fair value measurement will fall within the lowest level input that is significant to the fair value measurement in its entirety. The Company periodically evaluates financial assets and liabilities subject to fair value measurements to determine the appropriate level at which to classify them each reporting period. This determination requires the Company to make judgments as to the significance of inputs used in determining fair value and where such inputs lie within the ASC 820 hierarchy.
Earnings Per Share	Basic net loss per common share is determined by dividing net loss attributable to common stockholders by the weighted-average number of common shares outstanding during the period, without consideration of common stock equivalents. Diluted net loss per share is computed by dividing net loss attributable to common stockholders by the weighted-average number of Common Stock and Common Stock equivalents outstanding for the period. The treasury stock method is used to determine the dilutive effect of the Company’s stock option, RSU and warrant grants and the if-converted method is used to determine the dilutive effect of the Company’s contingently redeemable warrants.

Net Loss Per Share Attributable to Common Stockholders - Summary of Basic and Diluted Earnings Per Share (Detail) - USD ($)	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Earnings Per Share [Abstract]
Net loss	$ (3,077,273)	$ (9,565,077)
Basic net loss per common share (in dollars per share)	$ (2.46)	$ (9.17)
Diluted net loss per common share (in dollars per share)	$ (2.46)	$ (9.17)
Basic weighted average common shares outstanding (in shares)	1,250,498	1,043,138
Diluted weighted average common shares outstanding (in shares)	1,250,498	1,043,138

- Definition

The amount of net income (loss) for the period per each share of common stock or unit outstanding during the reporting period.

+ References

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+ Details

- Definition

The amount of net income (loss) for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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+ Details

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

+ References

+ Details

Commitments and Contingencies	3 Months Ended
Commitments and Contingencies	Mar. 31, 2024
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies	Commitments and Contingencies Maryland Biotechnology Center Grant In May 2012, the Company entered into a Translational Research Award Agreement, effective May 23, 2012 and further amended in 2013 (the "Award Agreement") with the Department of Business & Economic Development with the State of Maryland, Maryland Biotechnology Center (“MBC”). The mission of MBC is to integrate entrepreneurial strategies to stimulate the transformation of scientific discovery and intellectual assets into capital formation and business development. Under the Award Agreement, MBC provided $325,000 to the Company for research on its artificial Antigen Presenting Cell ("aAPC") for cancer immunotherapy. This grant was recorded as income in 2012 and 2013, as the Company incurred the expenses which qualified it for the grant. The Company must repay the funds through annual payments calculated at 3% of annual revenues for the preceding year. Payments shall continue for 10 years after the first payment date and may total up to 200% of the total grant amount. The end date of the agreement is defined as January 31, 2024, or when any and all repayments due to MBC have been made. If the Company does not earn any revenue, the grant does not need to be repaid. Through March 31, 2024, no revenue has been recorded, therefore, no payments to MBC are currently due. Johns Hopkins University Exclusive License Agreement The Company entered into an Exclusive License Agreement with Johns Hopkins University (“JHU”) effective June 2011, which was amended and restated in January 2017 (the "A&R JHU License Agreement"), under which there are license fees, royalties, and milestone payments. As part of the agreement, the Company acquired a perpetual, exclusive license from JHU covering its invention related to Antigen Specific T cells. JHU was also entitled to milestone fees of $75,000 in connection with clinical trial milestones. For the first licensed product or licensed service in the therapeutic field, the Company may be required to pay JHU additional aggregate milestone fees of $1.6 million for clinical and regulatory milestone fees. The Company may be required to pay JHU reduced milestone fees for the second and third licensed products or licensed services in the therapeutic field in connection with clinical and regulatory milestones. In the diagnostic field, the Company may be required to pay JHU aggregate milestone fees of $0.4 million for the first licensed product, or licensed service and reduced milestone fees for the second and third licensed products, or licensed services in connection with regulatory and commercial milestones. The Company may be required to pay JHU aggregate milestone fees of $100,000 for commercial milestones for the first licensed product or licensed service in the non-clinical field. In the aggregate, the Company may be required to pay JHU additional milestone fees of up to $4.2 million for all clinical, regulatory and commercial milestones for all licensed products or licensed services in the therapeutic field, the diagnostic field and the non-clinical field. The Company may also be required to pay royalties in the low to upper mid-single digits on net sales of therapeutic products, diagnostic products and non-clinical products. The Company may also be required to pay royalties in the low to upper single digits on net sales of licensed services in therapeutic products, diagnostic products and non-clinical products. The Company is required to make minimum annual royalty payments of $100,000 to JHU under the A&R JHU License Agreement. The Company may also be required to pay JHU a low double digit percentage not to exceed 15%, of any non-royalty sublicense consideration the Company receives. The Company will record a liability when such events become probable of occurring. The Company has not reached any of the milestones or transacted its first commercial sale as of March 31, 2024. The Company must make minimum royalty payments, which began upon the fourth anniversary of the agreement and upon every anniversary thereafter during the term of the agreement, which offset future royalties per above owed to JHU. The Company has incurred $650,000 in cumulative minimum royalties from inception. Future annual minimum royalties consist of $100,000 due each year during the remaining term of the A&R JHU License Agreement. The Company records milestones, royalties and minimum royalties at the time when payments become probable. During each of the three months ended March 31, 2024 and 2023, the Company incurred $25,000 and $25,000, respectively, related to minimum royalties owed, which is included in research and development expenses on the accompanying statement of operations. The Company has accrued royalties of $75,000 as of March 31, 2024 and $50,000 as of December 31, 2023. Contingencies From time to time, the Company may be subject to various litigation and related matters arising in the ordinary course of business. The Company records a provision for a liability when it believes that it is both probable that a liability has been incurred and the amount can be reasonably estimated. Significant judgment is required to determine both probability and the estimated amount. As of March 31, 2024 and December 31, 2023, the Company was not involved in any material legal proceedings.

Nature of the Business (Details)	Feb. 02, 2024 USD ($) $ / shares shares	Oct. 18, 2023	Mar. 31, 2024 USD ($) $ / shares	Feb. 29, 2024 $ / shares shares	Dec. 31, 2023 USD ($) $ / shares
Class of Warrant or Right [Line Items]
Accumulated deficit \| $			$ 225,671,320		$ 222,594,047
Outstanding debt \| $			0
Cash and cash equivalents \| $			$ 4,452,898		$ 3,202,452
Reverse stock split, conversion ratio		0.04
Common stock, par value (in dollars per share) \| $ / shares	$ 0.0001		$ 0.0001		$ 0.0001
Registered Offering
Class of Warrant or Right [Line Items]
Shares issued (shares) \| shares	117,000
Offering price of common stock (in dollars per share) \| $ / shares	$ 12.05
Consideration received on transaction \| $	$ 3,700,000
Pre-Funded Warrants \| Registered Offering
Class of Warrant or Right [Line Items]
Number of securities called by warrants (in shares) \| shares	187,731
Offering price of warrants (in dollars per share) \| $ / shares	$ 12.049
Unregistered Warrants \| The Private Placement
Class of Warrant or Right [Line Items]
Number of securities called by warrants (in shares) \| shares	304,731			304,731
Exercise price of warrants (in dollars per share) \| $ / shares	$ 12.05			$ 12.05
Warrants, term	2 years

BALANCE SHEETS (Parenthetical)	Oct. 18, 2023	Mar. 31, 2024 $ / shares shares	Feb. 02, 2024 $ / shares	Dec. 31, 2023 $ / shares shares
Statement of Financial Position [Abstract]
Common stock, par value (in dollars per share) \| $ / shares		$ 0.0001	$ 0.0001	$ 0.0001
Authorized common stock (in shares)		250,000,000		250,000,000
Common stock, shares issued (in shares)		1,371,051		1,066,320
Common stock, shares outstanding (in shares)		1,371,051		1,066,320
Reverse stock split, conversion ratio	0.04

STATEMENTS OF CHANGES IN STOCKHOLDERS’ EQUITY (UNAUDITED) (Parenthetical)	Oct. 18, 2023
Statement of Stockholders' Equity [Abstract]
Reverse stock split, conversion ratio	0.04

Accrued Expenses

3 Months Ended

Mar. 31, 2024

Payables and Accruals [Abstract]

Accrued Expenses

A summary of the components of accrued expenses is as follows as of March 31, 2024 and December 31, 2023:


	March 31, 2024		December 31, 2023
Accrued research and development costs	$	3,224,274	$	3,148,021
Accrued salaries, benefits and related expenses	306,654		389,858
Accrued professional fees	149,950		131,226
Other accrued expenses	181,816		10,000
Total accrued expenses	$	3,862,694	$	3,679,105

Cash, Cash Equivalents, and Restricted Cash (Detail) - USD ($)	Mar. 31, 2024	Dec. 31, 2023	Mar. 31, 2023	Dec. 31, 2022
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents [Abstract]
Cash and cash equivalents	$ 4,452,898	$ 3,202,452
Restricted cash	20,000	20,000
Total cash, cash equivalents, and restricted cash	$ 4,472,898	$ 3,222,452	$ 22,370,215	$ 34,697,340

Stock-Based Compensation - Summary of RSU Activity (Details) - Restricted stock unit	3 Months Ended
	Mar. 31, 2024 $ / shares shares
Number of restricted units
Beginning balance (in shares) \| shares	26,460
Granted (in shares) \| shares	0
Settled (in shares) \| shares	0
Forfeited (in shares) \| shares	0
Ending balance (in shares) \| shares	26,460
Weighted Average Exercise Price
Beginning balance (in dollars per share) \| $ / shares	$ 11.36
Granted (in dollars per share) \| $ / shares	0
Settled (in dollars per share) \| $ / shares	0
Forfeited (in dollars per share) \| $ / shares	0
Ending balance (in dollars per share) \| $ / shares	$ 11.36